vi medicine informatics

Principle Alpha1 Antitrypsin


Deficiency of A1AT manifests itself by damaging the lungs.

Lung irritation:

A1AT Defense: Inhibits elastase

Thus deficiency leads to Alveolar wall injury

> Patients with a1-antitrypsin deficiency are also at risk for liver cirrhosis due to the accumulation of misfolded gene products of a1-antitrypsin in the hepatocellular endoplasmic reticulum
tags: copd - respiratory - principle