vi medicine informatics

Principle Hepatic Encephalopathy Lactulose


Normally: liver is the detox organ that converts ammonia to Urea that is eventually excreted in kidney.

Liver damage: (Cirrhosis, etc)

Liver is unable to convert ammonia to harmless Urea. Ammonia accumulates, goes through to the brain, penetrates the blood brain barrier and causes encephalopathy


confusion & asterixis

Treatment: Lactulose

Lactulose is a diasaccharide –> acidifies colonic content –> absorbable ammonia to non absorbable ammonium ions –> excreted/trapped in stool –> fecal nitrogen excretion Increase

contributer: sheeba tauhid imran

tags: gi