Oneliner_859

OneLiner

Sacubitril is a prodrug which gets activated to sacubitrilat via esterases. Sacubitrilat inhibits the enzyme neprilysin which degrades bradykinin (a potent vasodilator). In addition, neprilysin is responsible for degradation of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) -> action of ANP/BNP prolonged