vimatics

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Oneliner_2231

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Δ-Aminolevulinate synthase is the rate-limiting enzyme involved in heme synthesis, and it requires pyridoxine (vitamin B6) as a cofactor. A deficiency in pyridoxine, most commonly caused by isoniazid therapy, can lead to sideroblastic anemia and a cracking/scaling of the corners of the mouth (cheilosis).

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