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OneLiner

Early manifestations of Whipple disease usually include migratory arthralgia that affects the large joints. Because the disease is relatively rare compared with other disorders affecting the joints, up to 50% of affected individuals are misdiagnosed and treated for suspected seronegative inflammatory arthritis. Later in the disease course, these patients develop abdominal pain and diarrhea (watery or steatorrhea) as a result of malabsorption. This can eventually lead to wasting and weight loss.