Oneliner_1836

OneLiner

Alkaptonuria> congenital deficiency of homogentisic acid oxidase, the third enzyme in the tyrosine degradation pathway. Homogentisic acid builds up in the body and polymerizes to form alkapton bodies. Alkapton bodies deposit to cause dark urine and dark cartilage. Patients also sometimes suffer from arthralgias and decreased joint mobility, but are otherwise healthy.