vimatics

vi medicine informatics

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Polycythemia vera is a myeloproliferative disorder that results from a JAK2 mutation, a non-receptor tyrosine kinase. This mutation leads to constitutive activation of the JAK2, signal transducer of activation (STAT) pathway and uncontrolled hematopoietic proliferation. This results in excessive RBCs, WBCs, and platelets

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