vimatics

vi medicine informatics

Oneliner_1148

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Tacrolimus acts by complexing with FK-binding protein 12, an immunophilin, creating a complex that inhibits T-cell calcineurin. This leads to the downstream effect of inhibiting IL-2 production and T-lymphocyte signaling. Tacrolimus is metabolized by cytochrome P-450 enzyme 3A.

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