Migrain

increase cerebral excitability –> diffuse cortical transmission –> coupled with CGRP activation and release –> neuropain transmission –> trigeminal spread (unilateral) and to the meningies
calcitonin gene-related peptide (CGRP
auro –> visual (scotomas) or sensory (uliteral extremity parasthesia)

The role of CGRP in migraine pathogenesis has been supported by the effectiveness of triptans ([5-HT1B/1D] receptor agonists that decrease CGRP release) and anti-CGRP antibodies (eg, erenumab) in treating migraine headaches.

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