Inheritance

Autosomal Dominant

• 50% Kids are affected with One affected Heterozygous parent
• variable penetrance, pleiotropy

Autosomal Recessive

• With One affected Parent: 50% kids are cariers, 25% affected, 25% normal
• Enzyme thigns
• more sever, 2/3rd probabliyy of carrier

X-Linked Dominant

• Transmitted by Father
• From affected father: 100% Females affected
• From mother: 50% kids affected

X-Linked Recessive

• From Mother: 50% sons carriers
• From Father: No transmission, but carriers
• skips generates