Endocrine Review 2
by
Phentermine, Diethylpropion, benzphetamine
- Sympathomimetics (NE)
- weightloss drugs (short therapy)
- CI in CVD patients
- Increased sensation of satiety, reduced calorie intake
Regular Insulin & NPH –> only human recomb insulin without any modifications to AA sequence
DKA treated with Regular Insulin!
Insulin Supresses Glucagon secretion by directly acting on pancreatic alpha cells!
Long standing T1-DM have alpha cell failure due to repeated inhibition by Insulin
- Results in Frequent Hypolgycemic events –>
T3 = short half life, mostly produced peripherally and can be normal in Primary Hypothyroidism
Infant, inc muscle tone, caramel/sugar smell urine, Autosomal recessive (hx of someone who died at a young age)
- branched chain alpha keto acid dehydrogenase requires TLCFN
- Rx: Thiamine
FGFReceptor-1 or KAL-1 gene defect –> failure of migration of GnRH secreting neurons from Olfactory placade (anosmia) –to–> Hypothalamus
Hypercholesterolemia, Familial Dyslipedmias: Key signs
- Type1: plasma LPL defect –> incrased Chylomicron, TG –> Acute Pancreatitis, milky appearing retinal vasculature (lipemia retinalis), eruptive xanthomas (small yellowish papules)
- creamy layer in supernatent
- Type2: LDL Receptor defect –> Inc LDL (plasma) –> Tendon Xanthomas, Xanthelasmas(medial eyelids), Premature CAD
- Type3: ApoE defect –> Inc VLDL, Chylomicrons –> Tuboeruptive Palmar Xanthomas
- Type4: ApoA-V defect –> Inc TG(>1000), VLDL –> Insulin sensitivity decreased –> DM
- Xanthelasmas: dermal accumulations of macrophages containing cholesterol, TG
tags: endocrine - review